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Every place we can confirm was used in Charleston, with what was filmed there and how to get in. All of it free to read. The routes are what put them in an order that makes a day.
Each has a page of its own with what was filmed there and which routes visit it.
60 places
ProfReader, CC BY-SA 4.0Outer Banks · Where John B and Big John go looking in season three
360 Meeting St, Charleston, SC
Justin Moffitt, CC BY-SA 4.0Outer Banks · UNC Chapel Hill Law Library
95 Calhoun St, Charleston, SC
Warren LeMay, CC0Dear John · The barbecue, and the summer
Outer Banks · The walking-and-talking beach
Sullivan's Island, SC
Ron Cogswell, CC BY 2.0, via FlickrOuter Banks · The ferry dock
10 Wharfside St, Charleston, SC

Outer Banks · The Piety Street Club
251 E Bay St, Charleston, SC
Warren LeMay, CC BY-SA 2.0Outer Banks · The church, outside
150 Meeting St, Charleston, SC

Outer Banks · The shop before UNC
149 King St, Charleston, SC
Warren LeMay, CC0Outer Banks · The church above the catacombs
4 Archdale St, Charleston, SC
Jpayton1234, CC BY-SA 4.0Outer Banks · The walk from the ferry
Washington Square, Charleston, SC
Daniel Mayer, CC BY-SA 3.0Outer Banks · The catacombs
122 E Bay St, Charleston, SC
JonathanLamb, CC BY 3.0Outer Banks · Where Pope and Cleo talk, in season three, episode three
Waterfront Park, Charleston, SC
Elizabeth Worthy, CC BY 2.0Outer Banks · 27 King Street, Carla Limbrey's house
21 E Battery, Charleston, SC
Photographed in 1896 by J.C. Olmsted. National Park Service, public domainOuter Banks · Carlos Singh's manor, in part
2 Meeting St, Charleston, SC
Brian Stansberry, CC BY 3.0, via Wikimedia CommonsOuter Banks · Hawk's Nest tower
Palmetto Islands County Park, Mount Pleasant, SC
RJ Matthews, CC BY-SA 3.0Outer Banks · The Kildare docks
Charleston Harbor Marina, Mount Pleasant, SC

Outer Banks · Kildare's Main Street
The Notebook · The ice cream date
Pitt St, Mount Pleasant, SC
Photo: Warren LeMay, CC BY-SA 2.0, via FlickrOuter Banks · Downtown Kildare
Old Village, Mount Pleasant, SC

Outer Banks · Kildare County Sheriff's Station
281 Venning St, Mount Pleasant, SC
Lightbulb Noob, CC BY-SA 4.0Outer Banks · The Kildare waterfront
Shem Creek, Mount Pleasant, SC

Outer Banks · Kiara's family restaurant
106 Haddrell St, Mount Pleasant, SC

Outer Banks · Heyward's Seafood
248 Magwood Ln, Mount Pleasant, SC
Outer Banks · Hollis's boat
1610 Ben Sawyer Blvd, Mount Pleasant, SC
Outer Banks · The outdoor cinema
3535 Wando Plantation Way, Mount Pleasant, SC
Outer Banks · Pelican Marina
1313 Shrimp Boat Ln, Mount Pleasant, SC
Outer Banks · The church where Lana gives her statement
604 Pitt St, Mount Pleasant, SC
Outer Banks · The Carrera house
202 McCants Dr, Mount Pleasant, SC
w_lemay, CC0Outer Banks · The crossing between the two halves
Arthur Ravenel Jr. Bridge, Charleston, SC
Warren LeMay, CC0Outer Banks · Tannyhill Plantation
266 St Margaret St, Charleston, SC
Er-nay, CC BY-SA 4.0Outer Banks · Where they take the jet ski
Breach Inlet, Sullivan's Island, SC
Kurtis Garbutt, CC BY 2.0Outer Banks · The lighthouse everyone gets wrong
Folly Beach, SC
DThomson7, CC BY-SA 3.0Outer Banks · The Island Club
Kiawah Island, SC
Outer Banks · The Island Inn
3772 Seabrook Island Rd, Seabrook Island, SC
Evanoco, CC BY-SA 4.0Outer Banks · The long empty highway stretch north of town
Awendaw, SC
Outer Banks · Uninhabited water
Wando, SC
Outer Banks · The 7-Eleven
2223 Folly Rd, Charleston, SC
Outer Banks · The Summer Winds Motel
2545 Savannah Hwy, Charleston, SC
Ammodramus, CC0, via Wikimedia CommonsOuter Banks · John B's bell tower
McClellanville, SC
Ammodramus, CC0, via Wikimedia CommonsOuter Banks · Freedman's Assembly of God
1507 Cainhoy Rd, Wando, SC
Outer Banks · Pope's great-grandmother's apartment
140 S Main St, Summerville, SC
ProfReader, CC BY-SA 4.0, via Wikimedia CommonsOuter Banks · The Shoals
217 Fort Johnson Rd, Charleston, SC
Outer Banks · Kildare County Detention Center
2340 Avenue F, North Charleston, SC
Outer Banks · Kildare County High School
1484 Camp Rd, Charleston, SC
Photo: ProfReader, CC BY-SA 4.0, via Wikimedia CommonsOuter Banks · Kildare County Courthouse
1097 Navy Way, North Charleston, SC
Historic American Buildings Survey, after 1933. Library of Congress, public domainOuter Banks · The South American village
900 Stony Landing Rd, Moncks Corner, SC
Brian Stansberry, CC BY 3.0Outer Banks · Season three, episode five
Charleston Harbor, SC
ProfReader, CC BY-SA 4.0The Notebook · Where they lie in the road
King St at Mary St, Charleston, SC
P. Hughes, CC BY-SA 4.0The Patriot · The Black Swamp
The Notebook · The boat, and the birds
Cypress Gardens, Moncks Corner, SC
Warren LeMay, CC BY-SA 4.0The Notebook · The house on the corner
456 King St, Charleston, SC
Warren LeMay, CC0The Notebook · The cinema on the date, and the street outside it
446 King St, Charleston, SC
Warren LeMay, CC BY-SA 3.0The Notebook · The dance hall
387 King St, Charleston, SC
Heinz-Vale, CC BY-SA 4.0The Notebook · Allie's summer house, outside
Boone Hall, Mount Pleasant, SC
Warren LeMay, CC0Dear John · Where the phones start ringing
The Patriot · The South Carolina General Assembly
The Notebook · The college, playing a college in New York
66 George St, Charleston, SC

The Notebook · Where Noah sees them together
199 E Bay St, Charleston, SC
Daniel Mayer, CC BY-SA 3.0The Notebook · Allie's summer house, inside
16 Meeting St, Charleston, SC
City of North Charleston, CC BY-SA 2.0The Notebook · Where the two of them meet
Riverfront Park, North Charleston, SC

Outer Banks · Kildare's Main Street
The Notebook · The ice cream date
Pitt St, Mount Pleasant, SC
Dima Sergiyenko, CC BY-SA 4.0Dear John · The pier where John goes in after Savannah's bag
Front Beach, Isle of Palms, SC
Warren LeMay, CC0Dear John · The barbecue, and the summer
Outer Banks · The walking-and-talking beach
Sullivan's Island, SC
Christiana Davies, CC BY-SA 4.0Dear John · The African outpost
1214 Middle St, Sullivan's Island, SC
Warren LeMay, CC0, via Wikimedia CommonsDear John · The coin shop, unidentified
King St, Charleston, SC
Warren LeMay, CC0Dear John · Where the phones start ringing
The Patriot · The South Carolina General Assembly
The Notebook · The college, playing a college in New York
66 George St, Charleston, SC
CocoaBeachBoy, public domainDear John · The German hospital
171 Moultrie St, Charleston, SC
P. Hughes, CC BY-SA 4.0The Patriot · The Black Swamp
The Notebook · The boat, and the birds
Cypress Gardens, Moncks Corner, SC
Warren LeMay, CC BY-SA 2.0, via Wikimedia CommonsThe Patriot · The ball
4300 Ashley River Rd, Charleston, SC
Warren LeMay, CC0Dear John · Where the phones start ringing
The Patriot · The South Carolina General Assembly
The Notebook · The college, playing a college in New York
66 George St, Charleston, SC
Now the other question
Which of these are worth the drive, in what order, and how long it really takes.